Eprim Plus 1000mg Capsule

✔️ Uses of Eprim Plus 1000mg Capsule

• Atopic dermatitis
• Mastalgia, cyclical
• Lactation
• Atopic dermatitis in infants
• Diabetic neuropathy
• Dry eyes associated with Sjögren’s syndrome
• Infant formula fortification
• Nutritional deficiencies (EFAs)
• Premenstrual syndrome symptoms
• Raynaud’s disease
• Rheumatoid arthritis
• Seborrhoeic dermatitis (milk crust)
• Uremic skin symptoms

✔️ Side Effects of Eprim Plus 1000mg Capsule

Adverse effects are rare at recommended dosages. Overdose may cause loose stool and abdominal pain.

✔️ Benefits of Evening Primrose Oil

Evening Primrose oil is recommended during pregnancy for reducing the risk of preterm delivery, easing labor, and promoting the baby's brain and eye health. It supports cell membrane development for long-term health benefits.

• Bone-related problems: With anti-inflammatory properties, Evening Primrose oil reduces pain and inflammation, increases bone mass density, and strengthens bones. It's beneficial for preventing disorders like osteoporosis.
• Fertility: Abundant Omega-3 fatty acids in Evening Primrose oil improve fertility by positively impacting uterine activities, and increasing conception chances. It's recommended before ovulation.
• Premenstrual syndrome (PMS): Linoleic acid and Gamma-Linoleic acid in Evening Primrose oil help maintain hormonal balance, alleviating PMS symptoms such as excessive bleeding, bloating, irritability, headaches, and more.
• Menopause: Evening Primrose oil supports hormonal balance during menopause, reducing hot flashes, and depression, and improving social activity. Omega-6 fatty acids play a crucial role in overall hormonal function.
• Acne Prevention: Evening Primrose oil, with its GLA content, helps prevent acne by reducing skin cell lesions and inflammation, contributing to skin hydration.
• Skin Benefits: Regular use of Evening Primrose oil supplements promotes smooth, elastic, and firm skin, maintaining moisture and preventing various skin disorders.
• Hair Loss: Balancing hormones, Evening Primrose oil addresses hair loss due to hormonal fluctuations. It reduces dihydrotestosterone levels in men and counters thyroid and stress hormones in women.
• Heart Health: Evening Primrose oil lowers blood cholesterol levels, prevents cholesterol build-up in arteries, and enhances cardiovascular health, addressing underlying causes of heart diseases.
• Nerve Pain: The GLA in Evening Primrose oil helps alleviate nerve pain and inflammation, reducing severity and improving mobility.
• Migraines: Omega-6 fatty acids, Linoleic acid, Gamma Linoleic acid, and phenylalanine in Evening Primrose oil play a role in reducing migraine symptoms.
• Hyperactivity: Rich in omega-6 fatty acids, Evening Primrose oil helps reduce symptoms of Attention Deficit Hyperactivity Disorder (ADHD) by regulating brain functions and neurotransmitter systems.

✔️ Indication

Acne (pimples), Eczema, Breast pain, and Premenstrual syndrome (PMS) symptoms.

✔️ Pharmacology

Improvements in Essential Fatty Acid (EFA) Composition:

• Enhances the EFA composition of plasma, erythrocyte, and platelet lipids.
• Increases α-tocopherol levels in non-diabetic individuals and Type 1 diabetic patients.

Effects on Mother's Milk:

• Increases the total fat and EFA content of mother's milk.

Fatty Acid Composition in Serum Lipids and Adipose Tissue:

• Affects the fatty acid composition of serum lipids and adipose tissue, especially in men with low dihomo-gamma-linolenic acid (DGLA) levels.

Maintenance of Normal Cellular Structures:

• Plays a role in maintaining normal cellular structures.

Prostaglandin Pathway:

• Serves as the precursor of DGLA, which, in turn, is the parent of the 1-series prostanoids.
• Acts as a precursor of arachidonic acid, the parent of the 2-series prostanoids.

In Vitro Activity:

• Exhibits cytostatic activity on malignant cell lines.
• Suppresses cancer cell proliferation, particularly in human osteogenic sarcoma cells.

Bioactivity and GLA Content:

• Eprim Plus 1000 mg (EPO) supplies gamma-linolenic acid (GLA), contributing to its bioactivity.
• The bioactivity is primarily attributed to its GLA content.
• By supplying GLA, it overcomes the rate-limiting step in the metabolism of linoleic acid (LA).
• Upon ingestion, GLA is rapidly absorbed and converted directly to DGLA and other prostaglandin precursors.

✔️ Dosage & Administration of Eprim Plus 1000mg Capsule

The recommended dosage is one or two capsules two to three times daily or as advised by the physician.

✔️ Interaction

Evening Primrose oil may lead to certain side effects that should be taken into consideration:

Increased Bruising and Bleeding:

• Evening Primrose oil has been associated with an increased risk of bruising and bleeding.
• Caution is advised, especially in individuals with bleeding disorders, and it may worsen during surgeries.

Risk of Seizures:

• There is a reported association between the intake of evening primrose oil and an increased likelihood of seizures.
• Individuals with epilepsy and schizophrenia should avoid its use.

Interaction with Anticoagulant or Antiplatelet Medications:

• Evening Primrose oil may interact with medications that have anticoagulant or antiplatelet effects.
• Caution is recommended, and medical advice should be sought, especially for individuals taking such medications.

Interaction with Phenothiazines:

• Evening Primrose oil may interact with phenothiazines, which are a class of medications used for various mental health conditions.
• It's important to be cautious and consult a healthcare professional if using both.

Interaction with Anaesthetic Drugs:

• Evening Primrose oil may interact with anesthetic drugs.
• Individuals scheduled for surgery should avoid its intake, and it's advisable to inform healthcare providers about its use before any surgical procedures.

✔️ Contraindications

Previously, it was advised against the use of Eprim Plus 1000 mg supplements in patients diagnosed with schizophrenia or those already receiving epileptogenic drugs like phenothiazines. However, a recent analysis of clinical trials focusing on polyunsaturated fatty acids in the treatment of schizophrenia did not show a clear therapeutic or adverse effect of Eprim Plus 1000 mg supplements on schizophrenic patients. It indicates that there might not be a significant impact, either positive or negative, in this specific context.

✔️ Pregnancy & Lactation

• No Known Restrictions: There are no known restrictions on the use of Eprim Plus 1000 mg during pregnancy.
• Non-Teratogenic Based on Animal Studies: Animal studies suggest that Eprim Plus 1000 mg is non-teratogenic, meaning it does not cause malformations in the developing fetus.
• Components in Human Breast Milk: LA (Linoleic Acid), GLA (Gamma-Linolenic Acid), and DGLA (Dihomo-Gamma-Linolenic Acid) are important components of human breast milk.
• Reasonable to Assume Safety While Nursing: Given the presence of these essential components in breast milk, it is reasonable to assume that Eprim Plus 1000 mg may be taken while nursing.
• World Health Organization (WHO) Recommendation: According to the World Health Organization, pregnant or lactating women should obtain 5% of their total daily caloric intake from essential fatty acids (EFAs).

✔️ Precautions & Warnings

Allergic Reactions:

• If you are allergic to Evening primrose oilor any other medicines, inform your doctor. Allergic reactions can range from mild to severe, and your healthcare provider needs to be aware of any potential risks.

Pregnancy and Nursing:

• If you are pregnant or a nursing mother, it is advised to consult with your doctor before using EVENING PRIMROSE OIL. This is to ensure that the supplement is safe for you and your baby and that the potential benefits outweigh any risks.

Medical History:

• Inform your doctor if you have a history of blood disorders, seizures (fits), liver disease, kidney disease, or heart problems. Certain medical conditions may interact with the supplement, and your doctor needs this information to make informed recommendations.

Medication and Supplement Use:

• If you are currently taking any medications or supplements, discuss this with your doctor before using Evening primrose oil. There can be potential interactions between different substances, and your healthcare provider will need to assess the overall impact on your health.

Children Usage:

• Do not give Evening primrose oil to a child without medical advice. Children may have different dosage requirements and sensitivities, and it's essential to consult a healthcare professional for guidance.

Surgery Precaution:

• If you are planning to undergo surgery, inform your doctor that you are taking Evening primrose oil. This is important as the supplement may have interactions with medications used during surgery, and your healthcare team needs to be aware to ensure a safe procedure.

✔️ Storage Conditions

• Keep out of reach of children.
• Store away from direct sunlight.
• Store below 25°C in a dry place.